Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, Sulconazole mononitrate seems to interfere with the autolytic degradation of fungal DNA and RNA.

Sulconazole mononitrate在体外对皮肤癣菌、酵母菌和某些革兰氏阳性细菌具有广谱活性，浓度低于5 mg/L。研究表明，针对病原性酵母、皮肤癣菌和曲霉的代表种，sulconazole的RIF值与其他咪唑类化合物大体相似。Sulconazole的杀真菌能力取决于其浓度和接种细胞的生长阶段。Sulconazole还在体外显示出抗菌活性，MIC值低于12.5 mg/L。[1]

在临床对照研究中，已证实sulconazole 1%霜剂对于表浅性皮肤癣菌或酵母菌感染的患者具有疗效和安全性。为了最小化再感染的风险，治疗应在念珠菌感染、股癣、体癣和花斑癣患者中持续3周，而在脚癣患者中持续4周。[1]